The 49ers (2-2) will face the Cardinals (4-0) on Sunday at 4:25 p.m. ET at State Farm Stadium in Glendale, Arizona. The game will be televised by FOX. 

San Francisco, which is in its fifth season under coach Mike Shanahan, is coming off a 28-21 loss to the Seahawks, the team’s first NFC opponent this season. The 49ers trailed by as many as 14 points in the third quarter and were unable to make a comeback, as they could not build on a late touchdown score in the final two minutes. 

MORE: Why did the Patriots release Stephon Gilmore?

49ers quarterback Jimmy Garoppolo suffered a calf contusion in the first half of that game, forcing backup Trey Lance into the game. Lance completed 9-of-18 passes for 157 yards and two touchdowns and also had seven rushes for 41 yards. 

According to Mike Jones of USA TODAY, Lance could start for the 49ers on Sunday, as Garoppolo said previously he could miss multiple weeks of action. 

Arizona is arguably the best team in the NFL to this point, defeating the Rams — which beat the defending Super Bowl champion Tampa Bay Buccaneers on Sunday, Sept. 26 — 37-20 last Sunday on the road. The Cardinals have the NFL’s top-ranked scoring offense at 35.0 points per game, and quarterback Kyler Murray is viewed as the betting favorite for the league’s Most Valuable Player award. 

Arizona was ranked as the No. 1 squad on’s Power Rankings on Tuesday, with Around the NFL writer Dan Hanzus calling the Cardinals’ triumph a “certified, no-doubt-about-it,” kind of win. 

Here’s everything you need to know to watch the 49ers vs. Cardinals game on Sunday, including kickoff time, TV channels and a full Week 5 NFL schedule. 

MORE: Watch 49ers vs. Cardinals live with fuboTV (7-day free trial)

What channel is 49ers vs. Cardinals on today? 

    TV channel (national): FOX TV channel (San Francisco): KTVU FOX 2 TV channel (Arizona): FOX 10 Arizona Live stream: fuboTV

    Play-by-play analyst Chris Meyers will work with analyst Daryl Johnston and field reporter Jennifer Hale for Sunday’s 49ers-Cardinals game. 

    For those looking for radio information, the 49ers broadcast can be heard on Sirius XM channel 387, or the Cardinals broadcast can be heard on Sirius XM channel 227. 

    Viewers in Canada can watch the 49ers vs. Cardinals on DAZN, which has rights to every NFL game, as well as some CTV regional channels. 

    MORE: Fantasy Football Start ‘Em Sit ‘Em

    49ers vs. Cardinals start time 

      Date: Wednesday, Oct. 6 Time: 4:25 p.m. ET 

      San Francisco vs. Arizona is scheduled to start at 4:25 p.m. ET on Sunday, one of two afternoon games on FOX (Giants vs. Cowboys). 

      NFL schedule Week 5 

      Thursday, Oct. 7 GameTime (ET)TVLos Angeles at Seattle8:20 p.m.FOX

       Sunday, Oct. 10 GameTime (ET)TVNew York Jets at Atlanta9:30 a.m.NFL NetworkDetroit at Minnesota1 p.m.FOXNew Orleans at Washington1 p.m.CBSNew England at Houston1 p.m.CBSMiami at Tampa Bay1 p.m.CBSGreen Bay at Cincinnati1 p.m.FOXDenver at Pittsburgh1 p.m.FOXPhiladelphia at Carolina1 p.m.FOXTennessee at Jacksonville1 p.m.CBSCleveland at Los Angeles Chargers4:05 p.m.CBSChicago at Las Veg

      as4:05 p.m.CBSSan Francisco at Arizona4:25 p.m.FOXNew York Giants at Dallas4:25 p.m.FOXBuffalo at Kansas City8:20 p.m.NBC

      Monday, Oct. 11 GameTime (ET)TVIndianapolis at Baltimore8:15 p.m. ETESPN